Thursday, January 6, 2011

Study Finds Bowel Disease in Children with Autistic Symptoms

The full study is here: (Clinical presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic spectrum Disorder and Chronic Gastrointestinal symptoms)
Here is a PDF form so you can save for your own records:
Background: Children with developmental disorders experience chronic gastrointestinal symptoms.

Aims:To examine the nature of these gastrointestinal symptoms and histologic findings in children with autism spectrum/developmental disorders and ileocolonic disease.
Methods: Chart review. 143 autism spectrum/developmental disorder patients, with chronic gastrointestinal symptoms, undergoing diagnostic ileocolonoscopy.
Results: Diarrhea was present in 78%, abdominal pain in 59% and constipation in 36%. Ileal and/or colonic lymphonodular hyperplasia (LNH), defined as the presence of an increased number of enlarged lymphoid follicles, often with hyperactive germinal centers, was
present in 73.2%. Terminal ileum LNH presented visually in 67% and histologically in 73%. Colonic LNH was multifocal and presented histologically in 32%. Ileal and/or colonic inflammation presented in 74%, consisting primarily of active or chronic colitis (69%). Ileal
inflammation presented in 35%. Presence of LNH significantly predicted mucosal inflammation.

Patients with ileal and/or colonic LNH had lower mean/median age than those without; patients with ileal and/or colonic inflammation had lower mean/median age than those
without. There was a significant association between ileo and/or colonic inflammation or LNH, and onset of developmental disorder; plateaued or regressive onset conferred greater risk than early onset.

Conclusions: Patients with autism or related disorders exhibiting chronic gastrointestinal symptoms demonstrate ileal or colonic inflammation upon light microscopic examination of biopsy tissue. Further work is needed to determine whether resolution of histopathology
with appropriate therapy is accompanied by GI symptomatic and cognitive/behavioral improvement.

Keywords:ASD ileitis, colitis, lymphonodular hyperplasia
1 Assistant professor of pediatrics, New York University school of Medicine Director of Gastroenterology services, Thoughtful House Center for Children, 3001 Bee Caves Rd, Austin, Texas, 78746, UsA.

2 Associate Clinical professor of pediatrics, New York University school of Medicine, 550 1st Ave., New York, NY 10016, UsA.

3 Adjunct professor Touro College, 27-33 West 23rd st, New York, NY 10010, UsA.

4Thoughtful House Center for Children, 3001 Bee Caves Rd,
Austin, Texas, 78746, UsA.

Autism Insights 2010:2 1–11

© The author(s), publisher and licensee Libertas Academica Ltd.
This is an open access article. Unrestricted commercial use is permitted provided the original work is properly cited.

1 comment:

  1. I was vaccinated with the MMR vaccine about 2 weeks before my first son was conceived. Kaleb developed Crohn's disease at the age of one. I believe the MMR vaccine I received is the cause of his Crohn's disease. Thankfully, I read 3 anti-vaccination books while I was pregnant with him so I did not vaccinate him after he was born. Thanks for your post.