Tuesday, March 1, 2011

Guest Post: The Wakefield Controversy

The compilation and commentary below is *not from me* and has been reprinted anonymously with permission.

The Original Research

Andrew Wakefield’s 1998 Research

Here is a link to the entire paper:

A J Wakefield, S H Murch, A Anthony, J Linnell, D M Casson, M Malik, M Berelowitz, A P Dhillon, M A Thomson, P Harvey, A Valentine, S E Davies, J A Walker-Smith,” Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children”, THE LANCET • Vol 351 • February 28, 1998


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Here is The Lancet’s link:

Dr AJ Wakefield FRCS a , SH Murch MB b, A Anthony MB a, J Linnell PhD a, DM Casson MRCP b, M Malik MRCP b, M Berelowitz FRCPsych c, AP Dhillon MRCPath a, MA Thomson FRCP b, P Harvey FRCP d, A Valentine FRCR e, SE Davies MRCPath a, JA Walker-Smith FRCP a,” RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children”,THE LANCET • Vol 351 • February 28, 1998


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Here is Wakefield’s published response after retraction:

Andrew J Wakefield a, Peter Harvey a, John Linnell a,” MMR—responding to retraction” The Lancet, Volume 363, Issue 9417, Pages 1327 - 1328, 17 April 2004 doi:10.1016/S0140-6736(04)16017-0


The Firestorm

Here are my research files, sorry if they are messy.

Dr. Wakefield Demands Retraction for Hoax Run Against Proven Vaccine / Autism Link


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DR. ANDREW WAKEFIELD WAS RIGHT. BRIAN DEER IS THE LIAR. THERE WAS NO FRAUD. NO HOAX. HERE’S PROOF. 
JANUARY 26, 2011


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Documents emerge proving Dr Andrew Wakefield innocent; BMJ and Brian Deer caught misrepresenting the facts


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Wakefield Inquisitioners Have Their Day


The Lancet took twelve years to retract Dr. Wakefield's controversial MMR paper implicating vaccines in autism. They then made the decision to do so within days of the British General Medical Council hearing, which found Wakefield guilty of misconduct. Yet not a single parent ever had a complaint about Wakefield. And the parents of eight of the twelve children involved with Wakefield's retracted study supported him publicly. (http://www.ageofautism.com/2010/02/no-parent-ever-complained-to-gmc-public-statement-from-lancet-families-supports-the-mmr3.html) They were not allowed to testify at his GMC hearing.

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Commentary

"Vaccination is designed for the greater good. To protect the majority. And it does so at the expense of a minority...and that minority of children are those who are damaged by the vaccine. And that we don't know the size of that number because it's never been investigated properly. But none the less, even if you accept that that's a permissible ethical approach, that we can protect the majority at the expense of the minority, that minority, a group of children who have paid the price for protecting the rest of society, then therefore society has absolute moral and ethical obligation to care for those children for the rest of their lives. Period."

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Dr Andrew Wakefield - In His Own Words
GoldenHawk Projects. Films Produced by Alan Golding © GoldenHawk Projects 2010


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Commentary

The arcane considerations that Sheldon brings up insofar as they are intelligible in this context at all have nothing to do with basis on which the GMC came to their decision. We can go round and round in circles - which is presumably what Sheldon wants - but this is completely irrelevant to the case. The GMC says the doctors were in the wrong for one set of reasons and because their findings don't work - are at variance with the historical record - it is evident that Sheldon has to find others. Sheldon may be courteous but we can go on with his red-herring defense of the GMC for hundreds of posts and illuminate nothing.

Regarding the work by Dr. Wakefield et al, the parents sought help for their children and they responded and reported the results as a case study. Now in contrast, consider the investigative work by Pichichero et al. Despite a 1999 federal warning about Thimerosal, the Argentine investigators injected vaccines with Thimerosal with 50 percent mercury into newborns in order to measure their mercury in blood levels. Funding for this work included contracts with the US National Institutes of Health under the US Department of Health and Human Services.USPHS statement: “Because any potential risk is of concern, the AAP and the USPHS agree that the use of Thimerosal-containing vaccines should be reduced or eliminated.” See: http://pediatrics.aappublications.org/cgi/content/full/104/3/570 , 1999.Pichichero report:“… all vaccines were administered by the investigators at the time of the enrollment visit.” See pages 209 and 214 at http://pediatrics.aappublications.org/cgi/reprint/121/2/e208 , 2008.

"Why Medical Authorities Went to Such Extremes to Silence Dr. Andrew Wakefield"http://articles.mercola.com/sites/articles/archive/2010/04/10/wakefield-interview.aspx

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Articles of interest:

Wakefield has been mentioned numerous time so here's a transcript from an April 2010 interview. Warning it's a little long.
A Special Interview with Dr. Andrew Wakefield (Full Transcript)
By Dr. Mercola
DW: Dr. Andrew Wakefield, MD
DM: Dr. Joseph Mercola, DO

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The following link is to an article about a recently revealed (2010) pediatric study, in which 45% of more than 1,000 autistic children tested had gastrointestinal problems, many serious. Obviously, this supports the findings of Dr. Andy Wakefield et al:


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  The editor of The Lancet recently admitted the missteps the journal had made. "We used to think that we could publish speculative research which advanced interesting new ideas which may be wrong, but which were important to provoke debate and discussion," Dr. Richard Horton told the public radio program "On the Media." "We don't think that now."

NAA Says GMC Actions Against Wakefield Show Lack of Scientific Integrity
Decision viewed as further attempt to hinder scientific investigation of vaccine safety issues

      Today’s decision by the UK’s General Medical Council (GMC) to strike Dr. Andrew Wakefield from the medical registry provides further evidence that science linking vaccines and autism is being suppressed at the expense of children’s health, according to families affected by autism.  Dr. Wakefield co-authored the case series reported in the British Journal, The Lancet, in 1998, which identified a novel inflammatory bowel disease in children diagnosed with autism.  This association has been repeatedly confirmed by subsequent studies. [i] [ii] [iii] [iv] [v]The actual findings were not the subject of the GMC hearings which many parents believe to have been an attempt to derail future autism research efforts that might bring vaccine safety concerns to light.
      “Unquestionably, the GMC had predetermined they would find The Lancet doctors guilty of professional misconduct in an effort to discredit not only their work with these twelve children, but any possible association between the MMR vaccine and autism,” says Washington DC-based public interest attorney Jim Moody, Esq.  “They acted on two false premises:  first by confusing diagnostic clinical tests with research, and second by claiming there were no ethics committee approvals that covered the research aspects of The Lancet paper.  There was – but the prosecution failed in their duty to identify it."
      While government agencies at home and abroad claim a link between vaccines and autism has been disproved, supporters of Dr. Wakefield say the epidemiological studies purportedly exonerating the shots are fatally flawed and could never account for susceptible populations.  Repeated requests for studies comparing health outcomes in fully vaccinated versus unvaccinated populations have been ignored by federal health agencies.
      “With this decision, the GMC is taking an active part in the suppression of vaccine safety science,” said National Autism Association (NAA) board chair Lori McIlwain. “The message is clear, scientists who dare to question the safety of vaccines do so at the risk of their careers.  Meanwhile, public confidence in the vaccine program continues to erode, and desperately needed answers for families dealing with autism are further delayed."
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[i] Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report, Timothy Buie, MD, et al, Department of Pediatrics, Harvard Medical School Pediatrics, Vol. 125 Supplement January 2010
[ii] Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms, Arthur Krigsman, MD, et al, New York University School of Medicine, Autism Insights, 27 Jan 2010
[iii] Endoscopic and Histological Characteristics of the Digestive Mucosa in Autistic Children with gastro-Intestinal Symptoms.Gonzalez L, et al. ArchVenez Pueric Pediatr, 2005;69:19-25.
[iv] Panenteric IBD-like disease in a patient with regressive autism shown for the first time by wireless capsulenteroscopy: Another piece in the jig-saw of the gut-brain syndrome? Balzola F, et al. American Journal of Gastroenterology. 2005. 100(4):979-981.
[v] Childhood autism and eosinophilic colitis. Chen B, Girgis S, El-Matary W.. Digestion. 2010;81:127-9. Epub 2010 Jan 9].

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Commentary

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Commentary

It's mainstream news that has got this story totally wrong. Everything I linked is valid, including the parents speaking directly about their experiences with Dr. Wakefield, and the parents describing their children's vaccine injuries. Dr. Wakefield responded to parental concerns; he did not initiate the concerns, which arose from bad experiences with the vaccine -- adverse reactions resulting in very serious digestive issues and autism. You can holler all you want about dangerous diseases. That does not change the fact that these children's injuries need to be understood and treated. Dr. Wakefield was one of a few doctors willing to undertake the investigation and treatment of their serious health issues.

Consider that this was a case study with ethical approval. The parents sought help for their children and Dr. Wake et al responded. The First Do No Harm ethics approach was followed. No parents have indicated that any harm was done. After the case study report was published, the public became justly concerned about the implications of the triple jab MMR--the Pharma owned General Medical Council, the Pharma owned media, and the Pharma owned British government responded with persecution so that the MMR problems could be swept under the rug and Pharma could do business as usual. For a reputable viewpoint without Pharma bias, go to the links Twyla provided.
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Commentary
'"The parents' view of Wakefield is not relevant." REALLY? Parents’ views don't matter? You’re saying the views of the parents of the kids that Wakefield treated don't matter?? Some kangaroo court reading a verdict written before the trial started does though right? Your position is clear. My position is-The parents’ views are paramount. Andrew Wakefield is a hero. His work has been replicated and validated numerous times. It is your opinion that is not relevant.
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MMR—responding to retraction
Andrew J Wakefield a, Peter Harvey a, John Linnell a
Sir

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Here are some links to the Wakefield story:




Here are some scholarly links about MMR, autism, and bowel disease:



The Gary Null Show – Wakefield answers questions.
1/27/11


Investigative report on the subject of Dr. Andrew Wakefield and some associates involved in a series of clinical observations a scientific report published in the peer-reviewed journal the Lancet.  Subsequent attacks against Dr. Wakefield and the other scientists by one Brian Deer, an investigative journalist in England.   And then the British Medical Journals retraction and condemnation of Dr. Wakefield and the American Media siding completely with Brian Deer.

Wakefield Credentials

Dr. Andrew Wakefield is an academic gastroenterologist specializing in inflammatory bowel disease and the measles mumps rubella vaccine.  Is formally a member of the fellowship of the Royal College of Surgeons.  He has published more than 130 original scientific papers.  In 1998 he and his colleagues at the Royal Free Hospital in London reported a novel inflammatory bowel disease in children with developmental disorders such as autism.  Dr. Wakefield resisted pressure to stop his investigation into a possible link between the vaccines, intentional inflammation and autism.  He left the hospital in 2001 to further pursue his research into neurological injury to children and it’s possible relationship to environmental causes such as immunizations.   In 2001, he was awarded the fellowship of the Royal College Pathologist and he was a medical advisor to the British charity Viseral and a board member to the American charity for the medical interventions of autism.  Dr. Wakefield lost his job at the Royal Free Hospital and his career medical license as well.  The timing of the release of this report, the timing an release of all of this raises suspicions.   

Our investigation will ask the following questions:

Is Dr. Andrew Wakefield guilty of medical fraud?
Is he the person we should be focusing our interest in?

TIME STAMP 3:55

A Timeline

1995 – Rosemary Kessick sought out Dr. Andrew Wakefield to find out what happened to her son.  None of the other physicians seemed to know what the causes were or how to treat them.

1995-96 – Wakefield researches literature to investigate the possibilities initially thinking there was some form of disintegrative disorder.

Sept, 1996 – The first child of a series of children were admitted for clinical investigations and biopsies covered by 1995 ethics approval  - the ethics approval was given. [find documentation]

Sept 2-16, 1996 – The first 4 of 12 children, being seen on clinical need at the Royal Free Hospital.  That’s were they started to think autistic conditions, not disintegrative disorder.

Sept 16, 1996 -  The ethics approved applications made for research projects but were never carried out.   This was a project investigating as if a disintegrative disorder was the issue. 

December 1996 – The ethics approved the go ahead for this new research, again the doctors say it was never carried out.

They had multiple approvals.

TIME STAMP 5:46

Ethical Approval

I asked Brian Deer whether or not he had this information.  Indeed he said he did.  Was this information of approving testing on these children ever presented at court.  He said yes it was.  I wish to challenge Brian Deer.  A careful examination of the records does not prove that this information was indeed there.  In-fact when Brian Deer wrote his challenging article and I have a copy of it in my hands let me quote this.  “The Lancet study children where all litigants and 7 admitted before ethical approval”

Now this page was research from the investigative journalist Brian Deer, for the UK channel 4 television and Sunday Times in the campaign linking the MMR vaccine with autism.  In this it states the peoples names, the companies vaccine and the date they were admitted.   What I have and to my knowledge I know I’m the only journalist in the world to have the actual documents outside of Brian Deer from the Royal Free Hospital.    From the Royal Free Hospital University Dept of Gastroenterology the date 27 of February 1997, Miss Mareen Carol secretary of the ethics practice sub-committee.   Gives permission  for “taking of extra-mucosal biopsies for research purposes during the course of upper endoscopy in children”. {ask for document} Now I have multiple letters, on multiple occasions granting permission for the type of in-depth clinical observation and analysis that was necessary to determine what going on in these children.  I cannot find any evidence that that what I have in my hand that Brian Deer had was actually given to the court.  And I believe if had the court had saw that every single piece of reseach that he did on these children had been pre-approved in writing by the Royal Free Hospital.  That the doctors being challenged being Dr. Wakefield would have had a completely different outcome.

Time Stamp 8:42

My question then is why didn’t Brian Deer turn over all these documents that he had to the commission?  And then the other question which I’ll be asking one of the leading berristers to the Supreme Court Of England in all the civil litigation.  Is this legal, is it not legal? 

We have primaphasia evidence that all the doctors including Wakefield sought and received absolute incontrovertible complete approval to do the research on these children.

Now to a larger issue

Safety and Ethics

TIME STAMP:  9:33

We’ve been told vaccines are safe and effective.  

At no time has any governmental agency in the United States or the United Kingdom said that they were going to create or disperse into the population children or adults or senior citizens or pregnant women or those who are sick any vaccine that was highly experimental not proven safe of not proven effective.  With every single vaccine and with no exception there always done.  The only time there has been an exception was with all of the armed forces personal going into the Gulf War and they were given experimental vaccines Botulism and Anthrax with squalene and other unapproved for that use by the FDA the were given a waiver.  Interesting for 18 years I have been the only major journalist in the world trying to bring to the US attention to the VA to the defense department to the White House to various administrations major documentation showing that Gulf War Syndrome was a real, we were told it was not.  They were told it was all in their minds, and then we were told it was posttraumatic stress disorder.  There are now over 75,000 dead American solders who served in the Gulf War, 1st and 2nd Gulf.  Their deaths are attributable to the Gulf War Syndrome.  Many of those people never served in combat.  Many who suffer from GWS and who suffer from neurological disorders, gastrointestinal disorders, and immune infection disorders.  The only thing they had that was common and unique to them was the experimental vaccines.  They are still given those experimental vaccines, massive amounts.  But when asked for their medical records of which vaccines were given, what were in them.  The Defense Department the administration all have refused to acknowledge at any point that they had the right to this information.  And therefore no solder has been given all of the information, to the contrary in one case 70,ooo of those documents mysteriously disappeared. 

So we do have president for experimental vaccines causing massive biological disorder in some of the healthiest youngest people who could receive them and had no other previous disorders till they received those vaccines. 

There is no research proving the safety and ethics of any vaccine in combination or given separately in a placebo controlled study.  Therefore we have been mislead.

Case For Motive

Why have we been mislead.  The consequences if it is determined that the MMR vaccine was dangerous, just set aside autism and look at all the other conditions that may be contributing to would mean that the British Government would have been held legally responsible and therefore could have cost them over a trillion dollars in damages.  Virtually bankrupting the entire British Government.  There for I am seeking a cause of motive, why would the British Government and by extension the British Medical Journal and their British Medical Commission go after these doctors.  What would have been their motive? 

Prevalence Rate

In the United States, let me give actual statistics.  The following data is compiled from US individuals with disabilities education act (IDEA).  The data is state collected and shows the total of US young children ages 6-21 in full-time education with a formal diagnosis of the DSM-4 autism.  The total is updated every year and here’s what it is.  In 1994 there were 22,780 cases.  In 2009 there were 331,999, by extension in 2010 there were @ 400,000.  That is almost a 1500% increase in that relatively short period of time.


And that would mean there is no other disease not cancer, arthritis, obesity no disease in the entire US that has had a 1500% increase.  It is not possible to be due to genetics.

Case For Motive

The population in the US is approximately 312 million, and in the UK it’s 62 million and therefore the population in the UK is approximately 20% of that of that in the US and the health regimes the two country are broadly similar and so applying a 20% estimate to the US autism figures for young people ages 6-21 in full-time educations will give the UK estimate of about 87,000.  Now the cost of that, if it were shown that it were do to the vaccines would just be astronomical.  Therefore one more reason for cover-up. 

Time Stamp 15:20

Panelists

Dr. Andrew Wakefield

Jim Moody 
Dr. Wakefield’s US attorney, and current directory of the Family Advocacy Organization and National Autism Association and the research think tank Safe Minds.   He consults with the petitioners’ steering committee on autism cases in the VIC

Clifford Miller 
He is a Major Barrister, a Salister to the Supreme Court of Civil proceedings in Great Britain.  He specialized in matters involving vaccination science. 

Dr. Edward Yazbak
He is a board certified pediatrician since 1963, a fellow of the AAP.  He is a medical expert for the social security office disability judacation and review.  A former assistant clinical director of the Charles Chaplin Hospital, an associate member for the institute of health science at Brown University and directory of pediatrics at the Moonsocket Hospital in Rhode Island.  So for more than 35 years he has been a practicing board certified pediatrician and also he is a research scientist on auto-immune regressive autism and vaccine injury.  He’s extensively written and published in peer-review journals.  More importantly to our discussion Dr. Yazbak grandson is autistic and was treated at the Royal Free Hospital by Dr. Wakefield and Walker-Smith.     

Isabella Thomas
Has 2 autistic children, who were part of the original 12 patients at the Royal Free Hospital study.  And also a person who is speaking out on behalf of other parents.   

Related articles:

Thimerosal:

A sampling of a debate:

Bowel disease in children with autistic symptoms:
http://guggiedaly.blogspot.com/2011/01/study-finds-bowel-disease-in-children.html

3 comments:

  1. Wow! This is an amazing compilation, Guggie. Adding your inciteful commentary has helped me understand the situation more fully. I still firmly believe in keeping our children vax-free. Finding supportive information is vital and I appreciate your work and time spent on this.

    Miss you, fb buddy <3
    Zoie

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  2. only one thing missing from this list
    Selective Hearing , Brian Deer and the GMC.
    Features Brian Deer, and lancet Parents.


    http://www.youtube.com/watch?v=id_AxZ3zHAc

    Good work
    Mark

    ReplyDelete