Saturday, December 28, 2013

Medical Studies Show Chickenpox Vaccine Causes Disease, Shingles, Death

The studies below are provided for your reading convenience regarding chickenpox vaccination and resulting disease, shingles disease, death, sepsis and other issues.

Journal of Clinical Virology. 2013 Nov 1. pii: S1386-6532(13)00475-7. doi: 10.1016/j.jcv.2013.10.027. [Epub ahead of print]
Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: A case report and review of the literature.

"We describe a man with previously-undiagnosed human immunodeficiency virus (HIV) infection who received VZV vaccination and subsequently presented to a combat hospital in Afghanistan with disseminated varicella, respiratory failure, and sepsis. The patient recovered with ventilator and hemodynamic support, intravenous acyclovir, and empiric antibiotic therapy. DNA sequencing detected Oka strain virus from patient blood specimens." 

(Oka strain is from the vaccine, showing that patients with undiagnosed conditions can experience infection and complications after vaccination.)


Herpes zoster after varicella-zoster vaccination

"A five-year-old girl, vaccinated against varicella-zoster virus (VZV) presented with clinical symptoms of herpes zoster in the 6th cervical dermatome. A VZV direct immune-fluorescence assay was negative three times but additional genotypical analysis showed a VZV strain genotype 2 (Oka vaccine strain). Therefore the diagnosis of a breakthrough varicella disease with the vaccine strain was established. An immunodeficiency was ruled out and the patient responded well to the initiated therapy." 

(Shows that shingles can occur despite vaccination, that it can happen in a healthy child and that tests can be falsely negative.)

Human Vaccine Immunotherapy. 2013 Aug 27;10(1). [Epub ahead of print]
Fatal varicella due to the vaccine-strain varicella-zoster virus.

"The patient developed severe respiratory complications that worsened with each new crop of varicella lesions; vaccine-strain VZV was detected in the bronchial lavage specimen. Sepsis and multi-organ failure led to death...Providers should monitor for adverse reactions after varicella vaccination." 

(Shows that severe infection and complication can occur after vaccination and that infants should be tested for immune health before vaccinating.)


J Clin Virol. 2003 Jul;27(2):190-9.
Molecular diagnosis of zoster post varicella vaccination.

"VZV was isolated from zoster occurring 16 months after varicella vaccination in a 2-year-old infant. Including VZV wild-type and different Oka strains as controls, viral DNA fragments located in the open reading frames (ORF) 38, 54, 62 and the R5 variable repeat region were characterized by amplification and restriction fragment length polymorphisms (RFLP) analysis.
VZV vaccine strain Oka was definitely proven to be the causative virus in this case of zoster post vaccination."

(Shows that shingles in a toddler after vaccination was caused by the vaccine strain.)


Eur J Pediatr. 2002 Aug;161(8):442-4. Epub 2002 Jun 25.
Herpes zoster by reactivated vaccine varicella zoster virus in a healthy child.

"We report a healthy 2-year-old girl who developed an impressive herpes zoster infection 16 months after vaccination... As causative virus, VZV vaccine strain was identified...
Vaccine varicella zoster virus can occasionally reactivate in healthy children and present as herpes zoster. Virus characterisation is necessary to identify the strain and provide information on the incidence of occurrence."

(Shows that the vaccine can cause shingles in healthy patients after vaccination, and that specific viral testing is required to prove the strain and determine how often this happens.) 

Herpes zoster due to Oka vaccine strain of varicella zoster virus in an immunosuppressed child post cord blood transplant.

"A 5-year-old boy was vaccinated with the Oka strain of varicella zoster virus vaccine before cord blood transplant for chronic granulomatous disease in 2005. In 2006, he developed herpes zoster on his left arm. DNA from the vesicular rash confirmed the Oka vaccine strain of varicella zoster virus caused this complication."


Ann Emerg Med. 2009 Jun;53(6):792-5. doi: 10.1016/j.annemergmed.2008.10.023. Epub 2008 Nov 22.
Herpes zoster and meningitis resulting from reactivation of varicella vaccine virus in an immunocompetent child.

"We present one of the first cases of aseptic meningitis after herpes zoster caused by reactivation of vaccine-type varicella-zoster virus in an immunocompetent child. We also highlight the increasing role of both wild-type and vaccine strains of varicella-zoster virus as a cause of viral meningoencephalitis..."


Pediatr Infect Dis J. 2011 Mar;30(3):266-8. doi: 10.1097/INF.0b013e3181f63cf9.
Herpes zoster and meningitis due to reactivation of varicella vaccine virus in an immunocompetent child.

"In this article, we describe a previously immunized child who developed herpes zoster with meningitis. Vaccine strain of VZV was recovered from a skin swab and the cerebrospinal fluid. Reactivation of the vaccine strain of VZV should be recognized as a potential cause of meningitis in children."


Pediatr Infect Dis J. 2008 Sep;27(9):847-8. doi: 10.1097/INF.0b013e318170af75.
Vaccine-strain varicella zoster virus causing recurrent herpes zoster in an immunocompetent 2-year-old.

"We report a case of recurrent vaccine-strain herpes zoster in an immunocompetent 2-year-old child. Vaccine-strain VZV was identified through polymerase chain reaction"

(Shows that a sickly toddler had frequent cases of shingles caused by the vaccine strain.)


J Clin Microbiol. 2004 Dec;42(12):5604-8.
Genetic profile of an Oka varicella vaccine virus variant isolated from an infant with zoster.

"Varicella virus vaccine strain Oka (V-Oka) has in rare cases caused zoster in vaccinated people. Despite broad usage of V-Oka, little is known about varicella-zoster virus genomic sequence variation of strains in vaccine and isolates from patients with vaccine adverse events....Further studies will be needed to identify potential virulence factors in variant vaccine strains."

(Shows that they do not know enough about the vaccine viruses to find out how many people are being hurt by vaccination strains.)


Herpes zoster in childhood.


"Because varicella vaccine is a live attenuated virus, herpes zoster can develop in a vaccine recipient. ...The most common complications are secondary bacterial infection, depigmentation, and scarring...viral DNA analysis of the lesion by polymerase chain reaction or restriction fragment length polymorphism is necessary to differentiate wild from vaccine-type viruses."

(Shows that the vaccine can cause disease and that DNA testing is required to differentiate between natural strains and vaccine strains.)

Primary versus secondary failure after varicella vaccination: implications for interval between 2 doses.


"Literature to date indicates a relatively high rate of primary vaccine failure and limited evidence of secondary vaccine failure among 1-dose varicella vaccine recipients, suggesting that a short interval between 2 doses might be preferable in countries considering implementation of universal varicella vaccination to reduce breakthrough varicella."

Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report


"The patient had the condition with failure to thrive. The main complaint was more than three weeks of fever and rash. He had received the live attenuated Oka strain varicella vaccination approximately two weeks before the onset of rash. ...Live vaccine administration should be avoided in patients with immunodeficiency."

Primary vaccine failure after 1 dose of varicella vaccine in healthy children.


"Although vaccine effectiveness has usually been 85%, rates as low as 44% have been observed. Whether this is from primary or secondary vaccine failure-or both-is unclear...Our data contrast with reported seroconversion rates of 86%-96% by other VZV antibody tests and suggest that many cases of varicella in immunized children are due to primary vaccine failure. A second dose of varicella vaccine is expected to increase seroconversion rates and vaccine effectiveness."

(Translation: the original vaccine protocol failed so we recommend more vaccines.)

For more information on chickenpox and shingles see:

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